博雅计划—博雅计划：细胞生物学课题：干细胞分化与细胞信号通路原理解析及其在组织再生、骨损伤修复中的应用【大学组】

开始日期：

2023年6月10日

专业方向：

理工

导师：

Armando（帝国理工学院 Imperial College London (IC) 终身教授）

课程周期：

7周在线小组科研+5周论文辅导

语言：

英文

建议学生年级：

大学生

项目产出：

7周在线小组科研学习+5周论文指导学习 学术报告 EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等级别索引国际会议全文投递与发表指导（共同一作） 结业证书 成绩单

项目介绍：

本项目将使学生了解临床医生目前用于骨软骨置换的最前沿方法，本项目将从肌肉骨骼系统入手，分析肌肉骨骼功能，探究年轻运动员的骨质疏松症、骨关节炎和主要损伤类型。研究骨骼和软骨中骨细胞、成骨细胞和破骨细胞在人类衰老中的动态过程。以此提出血管生成对组织形成和整合的要求，实现骨软骨组织修复的临床工具的研发。并将这种新型治疗材料应用到临床实验中，带领学生分析传统骨软骨组织置换策略的优点和缺点（使用来自自愿捐赠者或自己患者的组织）、适合骨软骨置换的人工组织的临床要求、植入手术和术后随访、植入后恢复日常活动：患者之间的差异等。学生将在项目结束时，提交项目报告，进行成果展示。 个性化研究课题参考： 再生医学（心脏病发作后心脏组织再生的新方法） 健康老龄化和延长寿命（使人体组织恢复活力的策略，有可能活到 150 岁以上吗？） 组织工程（如何使用智能材料通过诱导干细胞分化为不同谱系来创造新组织） 将合成生物学与再生医学相结合（创造可用于创造新器官和组织的新原核生物） This project will expose students to the cutting-edge methods currently used by clinicians for osteochondral replacement, starting with the musculoskeletal system, analyzing musculoskeletal function, and exploring osteoporosis, osteoarthritis, and major injury types in young athletes. The dynamic process of osteocytes, osteoblasts and osteoclasts in bone and cartilage in human aging were studied. Next, the requirements of angiogenesis for tissue formation and integration are proposed, and the development of clinical tools for osteochondral tissue repair is analyzed. By using this therapeutic material to clinical experiments, the professor leads students to analyze the advantages and disadvantages of traditional osteochondral tissue replacement strategies (using tissue from voluntary donors or own patients), clinical requirements for artificial tissue suitable for osteochondral replacement, Implant surgery and postoperative follow-up, return to daily activities after implantation: differences between patients, etc. At the end of the project, students will submit a project report and present their results. Suggested Future Research Fields: Regenerative medicine (i.e. new approaches to regenerate cardiac tissue after heart attack) Healthy aging and increasing lifespan (i.e. Strategies to rejuvenate human tissues. Could it possible to live more than 150 years?) Tissue engineering (i.e. how to use smart materials to create new tissues by inducing the differentiation of stem cells into different lineages) Merging synthetic biology with regenerative medicine (i.e. to create new prokaryotic organisms that can be used to create new organs and tissues)